The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma
Identifieur interne : 006894 ( Main/Exploration ); précédent : 006893; suivant : 006895The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma
Auteurs : L. Feller [Afrique du Sud] ; Jn Masipa [Afrique du Sud] ; Nh Wood [Afrique du Sud] ; Ej Raubenheimer [Afrique du Sud] ; J. Lemmer [Afrique du Sud]Source :
- AIDS Research and Therapy [ 1742-6405 ] ; 2008.
Abstract
Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.
Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.
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DOI: 10.1186/1742-6405-5-2
PubMed: 18226270
PubMed Central: 2275292
Affiliations:
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Feller</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author><author><name sortKey="Masipa, Jn" sort="Masipa, Jn" uniqKey="Masipa J" first="Jn" last="Masipa">Jn Masipa</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Maxillofacial and Oral Surgery, University of Limpopo School of Dentistry, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Maxillofacial and Oral Surgery, University of Limpopo School of Dentistry, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author><author><name sortKey="Wood, Nh" sort="Wood, Nh" uniqKey="Wood N" first="Nh" last="Wood">Nh Wood</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author><author><name sortKey="Raubenheimer, Ej" sort="Raubenheimer, Ej" uniqKey="Raubenheimer E" first="Ej" last="Raubenheimer">Ej Raubenheimer</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Oral Pathology, University of Limpopo School of Dentistry, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Oral Pathology, University of Limpopo School of Dentistry, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author><author><name sortKey="Lemmer, J" sort="Lemmer, J" uniqKey="Lemmer J" first="J" last="Lemmer">J. Lemmer</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author></analytic><series><title level="j">AIDS Research and Therapy</title><idno type="eISSN">1742-6405</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. 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Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Feller, L" sort="Feller, L" uniqKey="Feller L" first="L" last="Feller">L. Feller</name></noRegion><name sortKey="Lemmer, J" sort="Lemmer, J" uniqKey="Lemmer J" first="J" last="Lemmer">J. Lemmer</name><name sortKey="Masipa, Jn" sort="Masipa, Jn" uniqKey="Masipa J" first="Jn" last="Masipa">Jn Masipa</name><name sortKey="Raubenheimer, Ej" sort="Raubenheimer, Ej" uniqKey="Raubenheimer E" first="Ej" last="Raubenheimer">Ej Raubenheimer</name><name sortKey="Wood, Nh" sort="Wood, Nh" uniqKey="Wood N" first="Nh" last="Wood">Nh Wood</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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